You may know that it is possible for USB devices to be created that do
malicious things to your PC by committing deceptions right at the USB
protocol level. This kind of thing cannot be defeated by antivirus
software or erased by, for example, reformatting a USB stick.
For example, a device that is labelled as a USB storage stick could
actually identify to the PC as two devices, one the actual storage
device and the other a keyboard, that feeds malicious keystrokes at
carefully-chosen times. Alternatively, it can detect when the PC is
booting, and activate a separate partition containing a virus, which is
otherwise invisible to antivirus software, at only that point.
More details about such possibilities are available here
Here <https://github.com/robertfisk/USG/wiki> is an interesting project
to create a hardware device that will act as a “firewall” for untrusted
USB devices, to prevent malicious protocol exchanges from occurring
between them and your PC.
If you don’t want to build your own, there’s a link in the readme to buy
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